Tuesday, February 20, 2018

Article Index

10.0 Effects On Lipid Profiles

The studies by Hole et al. (2006) showed that pulp of Annona reticulata could significantly reduce total cholesterol, decrease low density lipoprotein and triglycerides (both these latter cholesterol types are classified as bad cholesterol) and increase high density lipoproteins (HDL is classified as good cholesterol) of rats treated with a chemical to induce heart disease (Figure 2).

In another study, (Gupta et al., 2005a) showed that fruit pulp of sugar apple (2.5-5.0 g/kg body weight) reduced total cholesterol level by 46% in normal and 32.4% in diabetic rabbits with increased HDL-cholesterol (Figure 3).  

Assuming that bioavailability in rabbits is similar to humans, for an 80kg human; this would be equivalent to eating a 400g, or about 80g dried, of fresh pulp (about a normal size custard apple fruit) per day.

The triglyceride/HDL ratio in the rabbits, a major predictor of heart disease in humans (Gaziano et al., 1997), was halved (Figure 4).

figure2

figure2a
Figure 2. Effects of dried Annona reticulata fruit (ARF) on lipid profile of rats isoproterenol-induced to produce myocardial infarcts (Hole et al., 2006).  MI=Induced myocardial infarct (heart disease). CHOL=cholesterol, HDL=high density lipoprotein, LDL=low density lipoprotein, TRIGLY= triglyceride.

figure3

Figure 3.  Effect of feeding sugar apple (Annona squamosa) fruit pulp (5g/kg) for one month on lipid profile of normal and diabetic rabbits (Gupta et al., 2005a).  CHOL=cholesterol, HDL=high density lipoprotein, LDL=low density lipoprotein, TRIGLY= triglyceride.

figure4

Figure 4. Effects of feeding sugar apple (Annona squamosa ) fruit pulp (5g/kg) for one month on triglyceride/HDL ratio of rabbits, a major predictor of heart disease in humans (based on Gupta et al., 2005a).

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